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Genetic and epigenetic alterations of DLC-1, a candidate tumor suppressor gene, in nasopharyngeal carcinoma.

Acta biochimica et biophysica Sinica - 1 May 2006

Peng Dan, Ren Cai-Ping, Yi Hong-Mei, Zhou Liang, Yang Xu-Yu, Li Hui, Yao Kai-Tai

Abstract excerpt

The DLC-1 gene, located at the human chromosome region 8p22, behaves like a tumor suppressor gene and is frequently deleted in diverse tumors. The deletion of 8p22 is not an uncommon event in nasopharyngeal carcinoma (NPC), therefore we explored the expression levels of the DLC-1 gene in NPCs and NPC cell lines by reverse transcription-polymerase chain reaction. The results showed the mRNA level of DLC-1 was...

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PMID: 16680376
DOI: 10.1111/j.1745-7270.2006.00164.x

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