Article
LIM domain only 2 protein expression, LMO2 germline genetic variation, and overall survival in diffuse large B-cell lymphoma in the pre-rituximab era.
Leukemia & lymphoma - 1 Jun 2012
Cerhan James R, Natkunam Yasodha, Morton Lindsay M, Maurer Matthew J, Asmann Yan, Habermann Thomas M, Vasef Mohammad A, Cozen Wendy, Lynch Charles F, Allmer Cristine, Slager Susan L, Lossos Izidore S, Chanock Stephen J, Rothman Nathaniel, Hartge Patricia, Dogan Ahmet, Wang Sophia S
Abstract excerpt
Both LMO2 (LIM domain only 2) mRNA and protein expression in diffuse large B-cell lymphoma (DLBCL) have been associated with superior survival. However, a role for germline genetic variation in LMO2 has not been previously reported. Immunohistochemistry (IHC) for LMO2 was conducted on tumor tissue from diagnostic biopsies, and 20 tag single nucleotide polymorphisms (SNPs) from LMO2 were genotyped from germline...
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