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Article

LMO3 Interacts with Neuronal Transcription Factor, HEN2, and Acts as an Oncogene in Neuroblastoma

1 Jun 2005

Abstract excerpt

LIM-only proteins (LMO), which consist of LMO1, LMO2, LMO3, and LMO4, are involved in cell fate determination and differentiation during embryonic development. Accumulating evidence suggests that LMO1 and LMO2 act as oncogenic proteins in T-cell acute lymphoblastic leukemia, whereas LMO4 has recently been implicated in the genesis of breast cancer. However, little is known about the role of LMO3 in either...

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Identifiers

PMID: 15930276
DOI: 10.1158/0008-5472.can-04-4630

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Related research

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LMO3 Interacts with Neuronal Transcription Factor, HEN2, and Acts as an Oncogene in NeuroblastomaPMID 15930276Read ↗

Oncogenic LMO3 Collaborates with HEN2 to Enhance Neuroblastoma Cell Growth through Transactivation of Mash1Semantic proximity Read ↗

Identification of LMO2 transcriptome and interactome in diffuse large B-cell lymphomaSemantic proximity Read ↗

LMO4 is an Essential Cofactor in the Snail2-Mediated Epithelial-to-Mesenchymal Transition of Neuroblastoma and Neural Crest CellsSemantic proximity Read ↗

Integrative genomics identifies LMO1 as a neuroblastoma oncogene.Semantic proximity Read ↗

LIM Domain Only-2 (LMO2) Induces T-Cell Leukemia by Two Distinct PathwaysSemantic proximity Read ↗

High expression of LMO2 predicts a favorable outcome in adult patients with BCR/ABL negative B-cell acute lymphoblastic leukemiaSemantic proximity Read ↗

The LIM domain gene <i>LMO4</i> inhibits differentiation of mammary epithelial cells <i>in vitro</i> and is overexpressed in breast cancerSemantic proximity Read ↗

LIM-Only Protein 4 (LMO4) and LIM Domain Binding Protein 1 (LDB1) Promote Growth and Metastasis of Human Head and Neck Cancer (LMO4 and LDB1 in Head and Neck Cancer)Semantic proximity Read ↗

HEN1 and HEN2: a subgroup of basic helix-loop-helix genes that are coexpressed in a human neuroblastoma.Semantic proximity Read ↗

Polo-like kinase 4 mediates epithelial–mesenchymal transition in neuroblastoma via PI3K/Akt signaling pathwaySemantic proximity Read ↗

LMO2 at 25 years: a paradigm of chromosomal translocation proteinsSemantic proximity Read ↗

Expression of LIM Protein GenesLmo1, Lmo2,andLmo3in Adult Mouse Hippocampus and Other Forebrain Regions: Differential Regulation by Seizure ActivitySemantic proximity Read ↗

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