Article
Evidence that interspecies polymorphism in the human and rat cholecystokinin receptor-2 affects structure of the binding site for the endogenous agonist cholecystokinin.
The Journal of biological chemistry - 10 Jun 2005
Langer Ingrid, Tikhonova Irina G, Travers Marie-Agnès, Archer-Lahlou Elodie, Escrieut Chantal, Maigret Bernard, Fourmy Daniel
Abstract excerpt
The cholecystokinin (CCK) receptor-2 exerts very important central and peripheral functions by binding the neuropeptides cholecystokinin or gastrin. Because this receptor is a potential therapeutic target, great interest has been devoted to the identification of efficient antagonists. However, in...
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