Article
B cell receptor light chain repertoires show signs of selection with differences between groups of healthy individuals and SLE patients.
Molecular immunology - 1 Jul 2012
Schoettler Nathan, Ni Dongyao, Weigert Martin
Abstract excerpt
We have developed a microarray to study the expression of L-chain V genes (V(L) genes) in healthy and SLE patient peripheral κ- and λ-sorted B cells. In all repertoires tested, one V(L) gene accounts for over 10% of all gene V(L) expression, consistent with positive selection acting on L-chains....
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