Article
Genetic evidence that lipoprotein(a) associates with atherosclerotic stenosis rather than venous thrombosis.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2012
Kamstrup Pia R, Tybjærg-Hansen Anne, Nordestgaard Børge G
Abstract excerpt
OBJECTIVE: The aim of the present study was to determine whether lipoprotein(a) [Lp(a)], considered a causal risk factor for cardiovascular disease, primarily promotes thrombosis or atherosclerosis. METHODS AND RESULTS: Using a Mendelian randomization study design, we measured plasma Lp(a) and genetically elevated Lp(a) levels through the LPA kringle IV type 2 repeat genotype in 41231 individuals. We included 2...
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