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Article

Endoplasmic reticulum stress controls M2 macrophage differentiation and foam cell formation.

The Journal of biological chemistry - 6 Apr 2012

Oh Jisu, Riek Amy E, Weng Sherry, Petty Marvin, Kim David, Colonna Marco, Cella Marina, Bernal-Mizrachi Carlos

Abstract excerpt

Macrophages are essential in atherosclerosis progression, but regulation of the M1 versus M2 phenotype and their role in cholesterol deposition are unclear. We demonstrate that endoplasmic reticulum (ER) stress is a key regulator of macrophage differentiation and cholesterol deposition. Macrophages from diabetic patients were classically or alternatively stimulated and then exposed to oxidized LDL. Alternative...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22356914
DOI: 10.1074/jbc.M111.338673
PMCID: PMC3320912

Genes

CD36

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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