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Article

STAT6 Upregulation Promotes M2 Macrophage Polarization to Suppress Atherosclerosis.

Medical science monitor basic research - 15 Jun 2017

Gong Min, Zhuo Xiaozhen, Ma Aiqun

Abstract excerpt

BACKGROUND Macrophages are highly heterogeneous and plastic cells that are involved in all stages of atherogenesis. They can undergo polarization by shifting between M1 and M2 functional phenotypes. However, the role of macrophage polarization and the molecular mechanism in modulating atherosclerotic plaque stability remain incompletely understood. Our study investigated the role of STAT6 in regulating macrophage...

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Share to Atherosclerosis
Share to Cell Polarity
Share to Lipoproteins, LDL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Macrophage Activation

Share to Plaque, Atherosclerotic

Share to RAW 264.7 Cells

Share to STAT6 Transcription Factor

Share to Wnt Signaling Pathway

Source

Open in PubMed Open full text

Identifiers

PMID: 28615615
DOI: 10.12659/msmbr.904014
PMCID: PMC5484610

Genes

STAT6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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