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Article

Genetic susceptibility to periapical disease: conditional contribution of MMP2 and MMP3 genes to the development of periapical lesions and healing response.

Journal of endodontics - 1 May 2012

Menezes-Silva Renato, Khaliq Shahryar, Deeley Kathleen, Letra Ariadne, Vieira Alexandre R

Abstract excerpt

INTRODUCTION: It has been proposed that individual genetic predisposition may contribute to a persistent apical periodontitis condition. Matrix metalloproteinases (MMPs) are associated with levels of inflammation and are involved in caries, pulpal, and periapical tissue destruction. MMPs also play a major role in bone resorption. In this study, we hypothesized that polymorphisms in MMP genes and their regulators...

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Source

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Identifiers

PMID: 22515887
DOI: 10.1016/j.joen.2012.02.009
PMCID: PMC3331995

Genes

MMP2
MMP3
MMP13
MMP14
MMP9
TIMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic susceptibility to periapical disease: conditional contribution of MMP2 and MMP3 genes to the development of periapical lesions and healing response.PMID 22515887Read ↗

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