Article
MMP1-1607 polymorphism increases the risk for periapical lesion development through the upregulation MMP-1 expression in association with pro-inflammatory milieu elements.
Journal of applied oral science : revista FOB - 1 Jan 2000
Trombone Ana Paula Favaro, Cavalla Franco, Silveira Elcia Maria Varize, Andreo Camile Bermejo, Francisconi Carolina Favaro, Fonseca Angélica Cristina, Letra Ariadne, Silva Renato Menezes, Garlet Gustavo Pompermaier
Abstract excerpt
OBJECTIVE: In this study, we evaluated the association between the MMP1-1607 polymorphism (rs1799750) and pro-inflammatory milieu elements with MMP-1 mRNA levels in vivo. MATERIAL AND METHODS: MMP1-1607 SNP and the mRNA levels of MMP-1, TNF-a, IFN-g, IL-17A, IL-21, IL-10, IL-4, IL-9, and FOXp3 were determined via RealTimePCR in DNA/RNA samples from patients presenting periapical granulomas (N=111, for both...
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