Article
MMP3 and TIMP1 variants contribute to chronic periodontitis and may be implicated in disease progression.
Journal of clinical periodontology - 1 Aug 2012
Letra Ariadne, Silva Renato M, Rylands Ryan J, Silveira Elcia M, de Souza Ana P, Wendell Steven K, Garlet Gustavo P, Vieira Alexandre R
Abstract excerpt
AIM: Matrix metalloproteinases (MMPs) play a key role in the tissue destruction characteristic of chronic periodontitis. The purpose of this study was to investigate the association of MMP and TIMP polymorphisms with chronic periodontitis in two populations. MATERIAL AND METHODS: A total of 34 polymorphisms spanning 12 MMP and 2 TIMP genes were genotyped in 401 individuals from Brazil (99 cases with chronic...
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