Article
Predisposition to colorectal cancer: exploiting copy number variation to identify novel predisposing genes and mechanisms.
Cytogenetic and genome research - 1 Jan 2008
Venkatachalam R, Ligtenberg M J L, Hoogerbrugge N, Geurts van Kessel A, Kuiper R P
Abstract excerpt
Although cancer is mostly regarded as an acquired disease, familial predisposition plays a significant role in many cancer types. Thus far, several high penetrant cancer predisposing genes have been identified. As yet, however, these genes explain only a fraction of the familial and/or hereditary cases of cancer. This has led to the exploration of the human genome for novel cancer predisposing genes. The...
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