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Article

Identification and characterization of ML352: a novel, noncompetitive inhibitor of the presynaptic choline transporter.

ACS chemical neuroscience - 18 Mar 2015

Ennis Elizabeth A, Wright Jane, Retzlaff Cassandra L, McManus Owen B, Lin Zhinong, Huang Xiaofang, Wu Meng, Li Min, Daniels J Scott, Lindsley Craig W, Hopkins Corey R, Blakely Randy D

Abstract excerpt

The high-affinity choline transporter (CHT) is the rate-limiting determinant of acetylcholine (ACh) synthesis, yet the transporter remains a largely undeveloped target for the detection and manipulation of synaptic cholinergic signaling. To expand CHT pharmacology, we pursued a high-throughput screen for novel CHT-targeted small molecules based on the electrogenic properties of transporter-mediated choline...

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PMID: 25560927
DOI: 10.1021/cn5001809
PMCID: PMC4367188

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