Article
The prototoxin lynx1 acts on nicotinic acetylcholine receptors to balance neuronal activity and survival in vivo.
Neuron - 7 Sept 2006
Miwa Julie M, Stevens Tanya R, King Sarah L, Caldarone Barbara J, Ibanez-Tallon Ines, Xiao Cheng, Fitzsimonds Reiko Maki, Pavlides Constantine, Lester Henry A, Picciotto Marina R, Heintz Nathaniel
Abstract excerpt
Nicotinic acetylcholine receptors (nAChRs) affect a wide array of biological processes, including learning and memory, attention, and addiction. lynx1, the founding member of a family of mammalian prototoxins, modulates nAChR function in vitro by altering agonist sensitivity and desensitization kinetics. Here we demonstrate, through the generation of lynx1 null mutant mice, that lynx1 modulates nAChR signaling in...
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