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Identification and functional analysis of choline transporter in tongue cancer: A novel molecular target for tongue cancer therapy

1 May 2016

Abstract excerpt

We examined the functional characteristics of choline uptake in human tongue carcinoma using the cell line HSC-3. Furthermore, we explored the possible correlation between the inhibition of choline uptake and apoptotic cell death. Both choline transporter-like protein 1 (CTL1) and CTL2 mRNAs and proteins were expressed, and were located in plasma membrane and mitochondria, respectively. Choline uptake was...

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PMID: 27262903
DOI: 10.1016/j.jphs.2016.04.022

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