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Article

Bacterial CYP153A monooxygenases for the synthesis of omega-hydroxylated fatty acids.

Chemical communications (Cambridge, England) - 25 May 2012

Honda Malca Sumire, Scheps Daniel, Kühnel Lisa, Venegas-Venegas Elena, Seifert Alexander, Nestl Bettina M, Hauer Bernhard

Abstract excerpt

CYP153A from Marinobacter aquaeolei has been identified as a fatty acid ω-hydroxylase with a broad substrate range. Two hotspots predicted to influence substrate specificity and selectivity were exchanged. Mutant G307A is 2- to 20-fold more active towards fatty acids than the wild-type. Residue L354 is determinant for the enzyme ω-regioselectivity.

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Source

Identifiers

PMID: 22513828
DOI: 10.1039/c2cc18103g

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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