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Article

Activation of multiple cancer pathways and tumor maintenance function of the 3q amplified oncogene<i>FNDC3B</i>

25 Apr 2012

Abstract excerpt

FNDC3B was recently identified in an oncogenomic screen for amplified oncogenes in hepatocellular carcinoma. It is located at 3q26 and is amplified in over 20% of cancers, usually as part of a broad amplified region encompassing the entire 3q arm. Consistent with an oncogenic role in multiple cancer types, we show here that overexpression of FNDC3B is capable of malignantly transforming mammary and kidney...

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PMID: 22510613
DOI: 10.4161/cc.20121

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