Article

<i>Disrupted in Renal Carcinoma 3</i> ( <i>DIRC3</i> ) impacts malignant phenotype and IGFBP5/IGF-1/Akt signaling axis in differentiated thyroid cancer

2023-01-24

Abstract excerpt

<h4>ABSTRACT</h4> Differentiated thyroid cancers (DTCs) are malignancies with ill-defined hereditary predisposition. Some germline variants influencing the risk of DTCs localize in disrupted in renal carcinoma 3 ( DIRC3 ), a poorly characterized long non-coding RNA (lncRNA) gene. Here, we characterized the function of DIRC3 in DTCs. We established that DIRC3 is downregulated in DTCs, and its high expression m...

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Literature Corpus work: f904f7e3-fa00-55f5-ae02-ff46b1e22ebc
DOI: 10.1101/2023.01.24.525402

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