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Article

KRAS/PI3K axis driven GTF3C6 expression and promotes LUAD via FAK pathway.

Journal of advanced research - 1 Apr 2025

Ji Xingzhao, Liu Mingqiang, Zhang Tianyi, Zhang Weiying, Xue Fuyuan, Wan Qiang, Liu Yi

Abstract excerpt

INTRODUCTION: Effective targeting drugs for KRAS mutation-mediated Lung Adenocarcinoma (LUAD) are currently are limited. OBJECTIVES: Investigating and intervening in the downstream key target genes of KRAS is crucial for clinically managing KRAS mutant-driven LUAD. GTF3C6, a newly identified member of the general transcription factor III (GTF3) family, plays a role in the transcription of RNA polymerase III (pol...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38685529
DOI: 10.1016/j.jare.2024.04.028
PMCID: PMC11976405

Genes

GTF3C6
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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