Article
Identifying Candidate Genes Associated with Sporadic Amyotrophic Lateral Sclerosis via Integrative Analysis of Transcriptome-Wide Association Study and Messenger RNA Expression Profile.
Cellular and molecular neurobiology - 1 Jan 2023
Li Ping, Cheng Shiqiang, Wen Yan, Cheng Bolun, Liu Li, Wu Xiuhua, Ao Xiang, Huang Zucheng, Liao Congrui, Li Shaen, Zhang Feng, Zhang Zhongmin
Abstract excerpt
Amyotrophic lateral sclerosis, a fatal neurodegeneration disease affecting motor neurons in the brain and spinal cord, is difficult to diagnose and treat. The objective of this study is to identify novel candidate genes related to ALS. Transcriptome-wide association study of ALS was conducted by integrating the genome-wide association study summary data (including 1234 ALS patients and 2850 controls) and...
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