Article
Aldehyde-stress resulting from Aldh2 mutation promotes osteoporosis due to impaired osteoblastogenesis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Sept 2012
Hoshi Hiroko, Hao Wu, Fujita Yoshinari, Funayama Atsushi, Miyauchi Yoshiteru, Hashimoto Kazuaki, Miyamoto Kana, Iwasaki Ryotaro, Sato Yuiko, Kobayashi Tami, Miyamoto Hiroya, Yoshida Shigeyuki, Mori Tomoaki, Kanagawa Hiroya, Katsuyama Eri, Fujie Atsuhiro, Kitagawa Kyoko, Nakayama Keiichi I, Kawamoto Toshihiro, Sano Motoaki, Fukuda Keiichi, Ohsawa Ikuroh, Ohta Shigeo, Morioka Hideo, Matsumoto Morio, Chiba Kazuhiro, Toyama Yoshiaki, Miyamoto Takeshi
Abstract excerpt
Osteoporosis is a complex disease with various causes, such as estrogen loss, genetics, and aging. Here we show that a dominant-negative form of aldehyde dehydrogenase 2 (ALDH2) protein, ALDH2*2, which is produced by a single nucleotide polymorphism (rs671), promotes osteoporosis due to impaired osteoblastogenesis. Aldh2 plays a role in alcohol-detoxification by acetaldehyde-detoxification; however, transgenic...
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