Article
A missense single nucleotide polymorphism in the ALDH2 gene, rs671, is associated with hip fracture.
Scientific reports - 27 Mar 2017
Takeshima Kenichiro, Nishiwaki Yuji, Suda Yasunori, Niki Yasuo, Sato Yuiko, Kobayashi Tami, Miyamoto Kana, Uchida Hisaya, Inokuchi Wataru, Tsuji Takashi, Funayama Atsushi, Nakamura Masaya, Matsumoto Morio, Toyama Yoshiaki, Miyamoto Takeshi
Abstract excerpt
Hip fracture is the most severe bone fragility fracture among osteoporotic injuries. Family history is a known risk factor for fracture and now included among criteria for osteoporosis diagnosis and treatment; however, genetic factors underlying family history favoring fracture remain to be elucidated. Here we demonstrate that a missense SNP in the ALDH2 gene, rs671 (ALDH2*2), is significantly associated with hip...
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