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Article

Differential effects of Bcl-2 on T and B cells in transgenic mice.

1 Dec 1992

Abstract excerpt

We have produced bcl-2 transgenic mice by using a construct which mimics the t(14;18) translocation in human follicular lymphomas. Although lymphoid tissues from all transgenic mice contained high levels of human Bcl-2 protein, transgene expression was differentially regulated within the B- and T-cell compartments of lines derived from various founder mice. We have characterized the phenotypes of two lines of...

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PMID: 1454823
DOI: 10.1073/pnas.89.23.11376

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Source receipt: pubmed, retrieved 7 Sept 2026.

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