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Article

Multiple mitochondrial introgression events and heteroplasmy in trypanosoma cruzi revealed by maxicircle MLST and next generation sequencing.

PLoS neglected tropical diseases - 1 Jan 2012

Messenger Louisa A, Llewellyn Martin S, Bhattacharyya Tapan, Franzén Oscar, Lewis Michael D, Ramírez Juan David, Carrasco Hernan J, Andersson Björn, Miles Michael A

Abstract excerpt

BACKGROUND: Mitochondrial DNA is a valuable taxonomic marker due to its relatively fast rate of evolution. In Trypanosoma cruzi, the causative agent of Chagas disease, the mitochondrial genome has a unique structural organization consisting of 20-50 maxicircles (∼20 kb) and thousands of minicircles (0.5-10 kb). T. cruzi is an early diverging protist displaying remarkable genetic heterogeneity and is recognized as...

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PMID: 22506081
DOI: 10.1371/journal.pntd.0001584
PMCID: PMC3323513

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