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Article

Maxicircle architecture and evolutionary insights into Trypanosoma cruzi complex.

PLoS neglected tropical diseases - 1 Aug 2021

Berná Luisa, Greif Gonzalo, Pita Sebastián, Faral-Tello Paula, Díaz-Viraqué Florencia, Souza Rita De Cássia Moreira De, Vallejo Gustavo Adolfo, Alvarez-Valin Fernando, Robello Carlos

Abstract excerpt

We sequenced maxicircles from T. cruzi strains representative of the species evolutionary diversity by using long-read sequencing, which allowed us to uncollapse their repetitive regions, finding that their real lengths range from 35 to 50 kb. T. cruzi maxicircles have a common architecture composed of four regions: coding region (CR), AT-rich region, short (SR) and long repeats (LR). Distribution of genes, both...

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PMID: 34437557
DOI: 10.1371/journal.pntd.0009719
PMCID: PMC8425572

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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