Article
Risk variant of oligodendrocyte lineage transcription factor 2 is associated with reduced white matter integrity.
Human brain mapping - 1 Sept 2013
Prata Diana P, Kanaan Richard A, Barker Gareth J, Shergill Sukhwinder, Woolley James, Georgieva Lyudmila, Picchioni Marco M, Kravariti Eugenia, Walshe Muriel, Allin Matt, Toulopoulou Timothea, Bramon Elvira, McDonald Colm, Giampietro Vincent, Murray Robin M, Brammer Michael, O'Donovan Michael, McGuire Philip
Abstract excerpt
The oligodendrocyte lineage transcription factor 2 (OLIG2) regulates the genesis of oligodendrocytes, the brain cells responsible for axonal myelination. Although it has been associated with psychiatric and neurological disorders, the impact of this gene on white matter integrity has never been investigated in humans. Using diffusion tensor imaging, we examined the effect of a single nucleotide polymorphism...
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