Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia.

doi:10.1073/pnas.0603029103

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Article

Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia.

Proceedings of the National Academy of Sciences of the United States of America - 15 Aug 2006

Georgieva Lyudmila, Moskvina Valentina, Peirce Tim, Norton Nadine, Bray Nicholas J, Jones Lesley, Holmans Peter, Macgregor Stuart, Zammit Stanley, Wilkinson Jennifer, Williams Hywel, Nikolov Ivan, Williams Nigel, Ivanov Dobril, Davis Kenneth L, Haroutunian Vahram, Buxbaum Joseph D, Craddock Nick, Kirov George, Owen Michael J, O'Donovan Michael C

Abstract excerpt

Abnormal oligodendrocyte function has been postulated as a primary etiological event in schizophrenia. Oligodendrocyte lineage transcription factor 2 (OLIG2) encodes a transcription factor central to oligodendrocyte development. Analysis of OLIG2 in a case-control sample (n = approximately 1,400) in the U.K. revealed several SNPs to be associated with schizophrenia (minimum P = 0.0001, gene-wide P = 0.0009). To...

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Identifiers

PMID: 16891421
DOI: 10.1073/pnas.0603029103
PMCID: PMC1567903

Genes

OLIG2
CNP
ERBB4
NRG1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia.PMID 16891421Read ↗

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Positive association between OLIG2 and schizophrenia in the Chinese Han population.Semantic proximity Read ↗

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A genetic family-based association study of OLIG2 in obsessive-compulsive disorder.Semantic proximity Read ↗

Risk variant of oligodendrocyte lineage transcription factor 2 is associated with reduced white matter integrity.Semantic proximity Read ↗

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