Article
White matter abnormalities in 22q11.2 deletion syndrome: preliminary associations with the Nogo-66 receptor gene and symptoms of psychosis.
Schizophrenia research - 1 Jan 2014
Perlstein Matthew D, Chohan Moeed R, Coman Ioana L, Antshel Kevin M, Fremont Wanda P, Gnirke Matthew H, Kikinis Zora, Middleton Frank A, Radoeva Petya D, Shenton Martha E, Kates Wendy R
Abstract excerpt
BACKGROUND: This study utilized diffusion tensor imaging (DTI) to analyze white matter tractography in the anterior limb of the internal capsule (ALIC), fornix, and uncinate fasciculus (UF) of individuals with 22q11.2 deletion syndrome and controls. Aberrations in these tracts have been previously associated with schizophrenia. With up to 25% of individuals with 22q11.2DS developing schizophrenia in adulthood, we...
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