Article
Isocitrate dehydrogenase 1 and 2 mutations in cholangiocarcinoma.
Human pathology - 1 Oct 2012
Kipp Benjamin R, Voss Jesse S, Kerr Sarah E, Barr Fritcher Emily G, Graham Rondell P, Zhang Lizhi, Highsmith W Edward, Zhang Jun, Roberts Lewis R, Gores Gregory J, Halling Kevin C
Abstract excerpt
Somatic mutations in isocitrate dehydrogenase 1 and 2 genes are common in gliomas and help stratify patients with brain cancer into histologic and molecular subtypes. However, these mutations are considered rare in other solid tumors. The aims of this study were to determine the frequency of isocitrate dehydrogenase 1 and 2 mutations in cholangiocarcinoma and to assess histopathologic differences between...
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