Isocitrate dehydrogenase 1 mutation sensitizes intrahepatic cholangiocarcinoma cells to MDM2 inhibitors

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Mutations in <italic>isocitrate dehydrogenase 1</italic> (<italic>IDH1</italic>^{<italic>mut</italic>}) occurs in 10-25% of intrahepatic cholangiocarcinoma (iCCA) cases. <italic>IDH1</italic>^{<italic>mut</italic>} produces oncometabolite D-2-hydroxyglutatrate (D-2-HG), which inhibits α-ketoglutarate-dependent dioxygenases activity, and further r...

Topics

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• Bile Duct Neoplasms
• Cholangiocarcinoma
• Gene Expression Regulation, Neoplastic
• Glycine
• Isocitrate Dehydrogenase
• Proto-Oncogene Proteins c-mdm2
• Pyridines
• Tumor Suppressor Protein p53

Identifiers and source

Literature Corpus work

3f3dd59b-79da-5829-88c4-3c704d0c7909

DOI

10.21203/rs.3.rs-6489065/v1