Article
Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping.
The oncologist - 1 Jan 2012
Borger Darrell R, Tanabe Kenneth K, Fan Kenneth C, Lopez Hector U, Fantin Valeria R, Straley Kimberly S, Schenkein David P, Hezel Aram F, Ancukiewicz Marek, Liebman Hannah M, Kwak Eunice L, Clark Jeffrey W, Ryan David P, Deshpande Vikram, Dias-Santagata Dora, Ellisen Leif W, Zhu Andrew X, Iafrate A John
Abstract excerpt
Cancers of origin in the gallbladder and bile ducts are rarely curable with current modalities of cancer treatment. Our clinical application of broad-based mutational profiling for patients diagnosed with a gastrointestinal malignancy has led to the novel discovery of mutations in the gene encoding isocitrate dehydrogenase 1 (IDH1) in tumors from a subset of patients with cholangiocarcinoma. A total of 287 tumors...
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