Identification of TUB as a novel candidate gene influencing body weight in humans.

doi:10.2337/diabetes.55.02.06.db05-0997

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Article

Identification of TUB as a novel candidate gene influencing body weight in humans.

Diabetes - 1 Feb 2006

Shiri-Sverdlov Ronit, Custers Anne, van Vliet-Ostaptchouk Jana V, van Gorp Patrick J J, Lindsey Patrick J, van Tilburg Jonathan H O, Zhernakova Sasha, Feskens Edith J M, van der A Daphne L, Dollé Martijn E T, van Haeften Timon W, Koeleman Bobby P C, Hofker Marten H, Wijmenga Cisca

Abstract excerpt

Previously, we identified a locus on 11p influencing obesity in families with type 2 diabetes. Based on mouse studies, we selected TUB as a functional candidate gene and performed association studies to determine whether this controls obesity. We analyzed the genotypes of 13 single nucleotide polymorphisms (SNPs) around TUB in 492 unrelated type 2 diabetic patients with known BMI values. One SNP (rs1528133) was...

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PMID: 16443771
DOI: 10.2337/diabetes.55.02.06.db05-0997

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