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Article

Roof and floor of the muscarinic binding pocket: variations in the binding modes of orthosteric ligands.

Molecular pharmacology - 1 Dec 2007

Goodwin J Alex, Hulme Edward C, Langmead Christopher J, Tehan Ben G

Abstract excerpt

Alanine substitution mutagenesis has been used to investigate residues that make up the roof and floor of the muscarinic binding pocket and regulate ligand access. We mutated the amino acids in the second extracellular loop of the M1 muscarinic acetylcholine receptor that are homologous to the cis-retinal contact residues in rhodopsin, the disulfide-bonded Cys178 and Cys98 that anchor the loop to transmembrane...

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PMID: 17848601
DOI: 10.1124/mol.107.038265

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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