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Article

Site-directed mutagenesis of the putative human muscarinic M2 receptor binding site.

European journal of pharmacology - 10 Sept 1999

Heitz F, Holzwarth J A, Gies J P, Pruss R M, Trumpp-Kallmeyer S, Hibert M F, Guenet C

Abstract excerpt

Experimental probing of the model of the muscarinic M2 receptor binding site proposed by Hibert et al. [Hibert, M.F., Trumpp-Kallmeyer, S., Bruinsvels, A., Hoflak, K., 1991. Three-dimensional models of neurotransmitter G-binding protein-coupled receptors. Mol. Pharmacol. 40, 8-15.] was achieved by mutating each amino-acid proposed to interact with muscarinic ligands. Pharmacological analysis of the different...

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Identifiers

PMID: 10513578
DOI: 10.1016/s0014-2999(99)00439-2

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