Article
CD133+, CD166+CD44+, and CD24+CD44+ phenotypes fail to reliably identify cell populations with cancer stem cell functional features in established human colorectal cancer cell lines.
Stem cells translational medicine - 1 Aug 2012
Muraro Manuele Giuseppe, Mele Valentina, Däster Silvio, Han Junyi, Heberer Michael, Cesare Spagnoli Giulio, Iezzi Giandomenica
Abstract excerpt
Increasing evidence that cancers originate from small populations of so-called cancer stem cells (CSCs), capable of surviving conventional chemotherapies and regenerating the original tumor, urges the development of novel CSC-targeted treatments. Screening of new anticancer compounds is conventionally conducted on established tumor cell lines, providing sufficient material for high-throughput studies. Whether...
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