Article
Colorectal cancer stem cell and chemoresistant colorectal cancer cell phenotypes and increased sensitivity to Notch pathway inhibitor.
Molecular medicine reports - 1 Aug 2015
Huang Rui, Wang Guiyu, Song Yanni, Tang Qingchao, You Qi, Liu Zheng, Chen Yinggang, Zhang Qian, Li Jiaying, Muhammand Shan, Wang Xishan
Abstract excerpt
Colorectal cancer stem cells (Co-CSCs) are a small subpopulation of tumor cells which have been proposed to be tumor-initiating cells in colorectal cancer (CRC) and to be implicated in resistance to standard chemotherapy. Chemoresistance is a common problem in the clinic. However, the interrelation between Co-CSCs and chemoresistant cells has yet to be elucidated. The present study investigated the Co-CSC...
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