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Article

Inhibition of Bcl-2 or IAP proteins does not provoke mutations in surviving cells.

Mutation research - 1 Jul 2015

Shekhar Tanmay M, Green Maja M, Rayner David M, Miles Mark A, Cutts Suzanne M, Hawkins Christine J

Abstract excerpt

Chemotherapy and radiotherapy can cause permanent damage to the genomes of surviving cells, provoking severe side effects such as second malignancies in some cancer survivors. Drugs that mimic the activity of death ligands, or antagonise pro-survival proteins of the Bcl-2 or IAP families have yie...

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PMID: 25916945
DOI: 10.1016/j.mrfmmm.2015.04.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25916945-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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