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Article

Mitochondrial Kv1.3 Channels as Target for Treatment of Multiple Myeloma

13 Apr 2022

Abstract excerpt

Despite several new developments in the treatment of multiple myeloma, all available therapies are only palliative without curative potential and all patients ultimately relapse. Thus, novel therapeutic options are urgently required to prolong survival of or to even cure myeloma. Here, we show that multiple myeloma cells express the potassium channel Kv1.3 in their mitochondria. The mitochondrial Kv1.3 inhibitors...

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PMID: 35454865
DOI: 10.3390/cancers14081955

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