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Article

Cisplatin cytotoxicity: a theoretical study of induced mutations.

Physical chemistry chemical physics : PCCP - 28 Sept 2012

Cerón-Carrasco José P, Jacquemin Denis, Cauët Emilie

Abstract excerpt

We investigate possible mutations in the genetic code induced by cisplatin with an approach combining molecular dynamics (MD) and hybrid quantum mechanics/molecular mechanics (QM/MM) calculations. Specifically, the impact of platination on the natural tautomeric equilibrium in guanine-cytosine (GC) base pairs is assessed to disclose the possible role played by non-canonical forms in anti-tumour activity. To...

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Identifiers

PMID: 22495492
DOI: 10.1039/c2cp40515f

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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