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[Molecular mechanisms of mutations, arising during formation of 8-hydroxyguanine in DNA].

Molekuliarnaia biologiia - 1 Jan 2000

Poltev V I, Chuprina V P, Nesterova E N

Abstract excerpt

To reveal the molecular mechanisms of genotoxic effects of oxidation and irradiation, molecular mechanics computations were performed for double-helical olygonucleotides with 8-oxoguanine:adenine (OG.A) pairs in two configurations. Substitution of a T.A pair by OG(syn).A one results in minor changes of intramolecular interaction energy and of the conformational parameters of helixes. Nearly all the interproton...

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PMID: 7990832

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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