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Article

BRCA1 as tumor suppressor: lord without its RING?

Breast cancer research : BCR - 10 Apr 2012

Elia Andrew E H, Elledge Stephen J

Abstract excerpt

BRCA1 is a tumor suppressor with critical roles in the maintenance of genomic stability. It encodes a large protein with an amino-terminal RING domain that possesses ubiquitin-ligase activity. Given the occurrence of numerous cancer-causing mutations within its RING domain, investigators have long suspected that BRCA1's ubiquitin ligase is important for its tumor suppression and DNA repair activities. Using...

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Identifiers

PMID: 22494569
DOI: 10.1186/bcr3118
PMCID: PMC3446363

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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