Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

BRCA1 loses the ring but lords over resistance.

The Journal of clinical investigation - 1 Aug 2016

Powell Simon N

Abstract excerpt

Germline breast cancer 1 (BRCA1) variants are associated with a high risk of breast and ovarian cancers. Many BRCA1-mediated cancers are initially responsive to platinum-based therapy; however, resistance commonly develops. The BRCA1185delAG mutation is common in the Ashkenazi Jewish population and has been thought to result in loss of function due to the introduction of a stop codon in the 5' region of the BRCA1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ovarian Neoplasms
Share to Breast Neoplasms
Share to BRCA1 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, BRCA1

Share to Germ-Line Mutation

Share to Homologous Recombination

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 27454288
DOI: 10.1172/JCI89209
PMCID: PMC4966308

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

BRCA1 loses the ring but lords over resistance.PMID 27454288Read ↗

RING domain-deficient BRCA1 promotes PARP inhibitor and platinum resistance.Semantic proximity Read ↗

BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1.Semantic proximity Read ↗

BRCA1 RING Function Is Essential for Tumor Suppression but Dispensable for Therapy ResistanceSemantic proximity Read ↗

BRCA1 as tumor suppressor: lord without its RING?Semantic proximity Read ↗

Overview of history and progress in BRCA1 research: the first BRCA1 decade.Semantic proximity Read ↗

A meta-analysis of clinical cases of reversion mutations in <i>BRCA</i> genes identifies signatures of DNA end-joining repair mechanisms driving therapy resistanceSemantic proximity Read ↗

BRCA1: mechanisms of inactivation and implications for management of patients.Semantic proximity Read ↗

New BRCA2 mutation in an Ashkenazi Jewish family with breast and ovarian cancer.Semantic proximity Read ↗

em BRCA1 em in cancer cell cycle and genomic stabilitySemantic proximity Read ↗

BRCA1 gene: function and deficiency.Semantic proximity Read ↗

Roles of BRCA1 and its interacting proteins.Semantic proximity Read ↗

Reversion mutations define minimal <i>BRCA1/2</i> requirements for therapy resistanceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.