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Article

Allostery in a disordered protein: oxidative modifications to α-synuclein act distally to regulate membrane binding.

Journal of the American Chemical Society - 11 May 2011

Sevcsik Eva, Trexler Adam J, Dunn Joanna M, Rhoades Elizabeth

Abstract excerpt

Both oxidative stress and aggregation of the protein α-synuclein (aS) have been implicated as key factors in the etiology of Parkinson's disease. Specifically, oxidative modifications to aS disrupt its binding to lipid membranes, an interaction considered critical to its native function. Here we seek to provide a mechanistic explanation for this phenomenon by investigating the effects of oxidative nitration of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21491910
DOI: 10.1021/ja2009554
PMCID: PMC3110780

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