Article
UG4 enhancer-driven GATA-2 and bone morphogenetic protein 4 complementation remedies the CAKUT phenotype in Gata2 hypomorphic mutant mice.
Molecular and cellular biology - 1 Jun 2012
Ainoya Keiko, Moriguchi Takashi, Ohmori Shin'ya, Souma Tomokazu, Takai Jun, Morita Masanobu, Chandler Kelly J, Mortlock Douglas P, Shimizu Ritsuko, Engel James Douglas, Lim Kim-Chew, Yamamoto Masayuki
Abstract excerpt
During renal development, the proper emergence of the ureteric bud (UB) from the Wolffian duct is essential for formation of the urinary system. Previously, we showed that expression of transcription factor GATA-2 in the urogenital primordium was demarcated anteroposteriorly into two domains that were regulated by separate enhancers. While GATA-2 expression in the caudal urogenital mesenchyme is controlled by the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.