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Article

Multiple, distant Gata2 enhancers specify temporally and tissue-specific patterning in the developing urogenital system.

Molecular and cellular biology - 1 Dec 2004

Khandekar Melin, Suzuki Norio, Lewton Jon, Yamamoto Masayuki, Engel James Douglas

Abstract excerpt

Transcription factor GATA-2 is expressed in a complex temporally and tissue-specific pattern within the developing embryo. Loss-of-function studies in the mouse showed that GATA-2 activity is first required during very early hematopoiesis. We subsequently showed that a 271-kbp yeast artificial chromosome (YAC) transgene could fully complement the loss of Gata2 hematopoietic function but that these YAC-rescued...

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Identifiers

PMID: 15542836
DOI: 10.1128/MCB.24.23.10263-10276.2004
PMCID: PMC529040

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Source receipt: pubmed, retrieved 7 Sept 2026.

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