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Article

Reduced BMP4 abundance in Gata2 hypomorphic mutant mice result in uropathies resembling human CAKUT.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Feb 2008

Hoshino Tomofumi, Shimizu Ritsuko, Ohmori Shinya, Nagano Masumi, Pan Xiaoqing, Ohneda Osamu, Khandekar Melin, Yamamoto Masayuki, Lim Kim-Chew, Engel James Douglas

Abstract excerpt

Constitutive loss of transcription factor GATA-2 leads to embryonic lethality from primitive erythropoietic failure. We serendipitously discovered an essential contribution of GATA-2 to urogenital development when the hematopoietic deficiency of Gata2 null mutant animals was complemented by a Gata2 yeast artificial chromosome (YAC) transgene; these mice died from a perinatal lethal urogenital abnormality. Here,...

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Source

Identifiers

PMID: 18233958
DOI: 10.1111/j.1365-2443.2007.01158.x

Genes

BMP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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