Article
The essential endoplasmic reticulum chaperone Rot1 is required for protein N- and O-glycosylation in yeast.
Glycobiology - 1 Jul 2012
Pasikowska Monika, Palamarczyk Grazyna, Lehle Ludwig
Abstract excerpt
Rot1 is an essential yeast protein originally shown to be implicated in such diverse processes such as β-1,6-glucan synthesis, actin cytoskeleton dynamics or lysis of autophagic bodies. More recently also a role as a molecular chaperone has been discovered. Here, we report that Rot1 interacts in a synthetic manner with Ost3, one of the nine subunits of the oligosaccharyltransferase (OST) complex, the key enzyme...
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