Article
ER stress induced by the OCH1 mutation triggers changes in lipid homeostasis in Kluyveromyces lactis.
Research in microbiology - 1 Jan 2000
Zanni Elena, Maulucci Giuseppe, Pomata Donatella, Buiarelli Francesca, Krasnowska Ewa K, Parasassi Tiziana, De Spirito Marco, Heipieper Hermann J, Uccelletti Daniela
Abstract excerpt
In Kluyveromyces lactis yeast, OCH1 encodes for the α-1,6-mannosyltrasferase that adds the initial α-1,6-mannose to the outer-chains of N-glycoproteins. Kloch1-1 mutant cells showed altered calcium homeostasis and endoplasmic reticulum (ER) stress. Since ER plays a major role in lipid biosynthesis and lipid droplet (LD) formation, herein the impact of Och1p depletion on lipid homeostasis was investigated....
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