Article
Functional characterization of the Hansenula polymorpha HOC1, OCH1, and OCR1 genes as members of the yeast OCH1 mannosyltransferase family involved in protein glycosylation.
The Journal of biological chemistry - 10 Mar 2006
Kim Moo Woong, Kim Eun Jung, Kim Jeong-Yoon, Park Jeong-Seok, Oh Doo-Byoung, Shimma Yoh-ichi, Chiba Yasunori, Jigami Yoshifumi, Rhee Sang Ki, Kang Hyun Ah
Abstract excerpt
The alpha-1,6-mannosyltransferase encoded by Saccharomyces cerevisiae OCH1 (ScOCH1) is responsible for the outer chain initiation of N-linked oligosaccharides. To identify the genes involved in the first step of outer chain biosynthesis in the methylotrophic yeast Hansenula polymorpha, we undertook the functional analysis of three H. polymorpha genes, HpHOC1, HpOCH1, and HpOCR1, that belong to the OCH1 family...
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