Article
Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease.
The Journal of clinical investigation - 1 Mar 1999
Holtzman D M, Bales K R, Wu S, Bhat P, Parsadanian M, Fagan A M, Chang L K, Sun Y, Paul S M
Abstract excerpt
The epsilon4 allele of apolipoprotein E (apo E) is associated with an increased risk for developing Alzheimer's disease (AD). This may be due to interactions between apo E and the amyloid-beta protein (Abeta). To assess the effects of human apo E isoforms on Abeta deposition in vivo, we bred apo...
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